Latest article: |
Novel Bcl-2 family inhibitors by fragment and virtual screening
 22 Apr 2008: This poster demonstrates that by using the EVOlution™ platform for fragment-based drug discovery (FBDD) and structure-based drug design, we have discovered by fragment and virtual screening, novel inhibitors of Bcl-2, Bcl-xL and Mcl-1. This has afforded to date four series of drug-like Bcl-2 family inhibitors with multiple actives in the micromolar range and several singleton hits.
Evotec technologies
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Recent articles: |
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Finnpipette Novus Multichannel – an ideal tool in a low-throughput crystallization laboratory
 21 Feb 2008: Protein crystallization generally starts with a screen to search for suitable crystallization conditions. A broad range of buffers, pH and precipitants are tested. This Technical Note describes the use of the Finnpipette Novus electronic multichannel pipette in low-throughput protein crystallization experiments.
Thermo Fisher Scientific
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CyBi®-CrystalCreator Workstation for the Automation of Sitting Drop Protein Crystallization
 27 Apr 2007: Recent developments in genomics and proteomics have led to an increase in the number of macromolecules requiring structural elucidation. Moreover, the increased size of complex proteins often requires the use of crystallography as a structural method. This poster demonstrates how CyBio’s CyBi®-CrystalCreator is able to complete the protein crystallization process in 6 plates per run.
CyBio AG
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Fully automated sitting drop protein crystallization with CyBi®-CrystalCreator using JBScreen Basic HTS Kit
27 Apr 2007: Knowledge of the three-dimensional structure of biological macromolecules can reveal essential information about their function, offering a unique opportunity to facilitate drug discovery. This application note describes screening experiments using the fully automated CyBi®-CrystalCreator in combination with a commercially available crystallization screen from Jena Bioscience.
CyBio AG
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Poster - Facilitating Low Volume Protein Crystallography Set-ups Using the mosquito® Liquid Handler
06 Feb 2006: The mosquito® offers fast positive displacement pipetting for accurate and reproducible aspiration and dispensing throughout the 50 nL-1.2 µL range, producing CVs of <8% at 50 nL irrespective of viscosity. Mosquito’s micropipettes are also disposable, thus guaranteeing zero cross-contamination where required.
TTP LabTech
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Miniaturization of Protein Crystallization
19 Oct 2005: The ability to reduce the volume of protein used in a protein crystallization experiment allows the number of conditions that can be screened to be maximized, ensuring a greater chance of crystal growth. With manual pipetting and indeed many automated liquid handlers the reduction of volume is limited to 1 uL. Cartesian dispensing technology from Genomic Solutions enables miniaturization of protein crystallization experiments to nanolitre volumes.
Genomic Solutions Ltd
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ScreenDeveloper Workstation for Protein Crystallization
13 Oct 2005: Protein crystallisation is a multi-factorial process that depends on the interplay between many independent parameters. To determine optimal crystallisation conditions, screens for testing various conditions can be developed and ready mixed precipitation solutions applied. To optimise this process HAMILTON has developed a protein crystallisation workstation based on the MICROLAB STAR line and ScreenDeveloper software allowing setup of experiments in a few simple steps.
HAMILTON Life Science Robotics
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Detection of Early-Stage Protein Crystallization using DPI
26 Sep 2005: Data first presented as a poster at BioScience 2005, 17th-21st July 2005, Glasgow, UK
Farfield Scientific Ltd
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